![]() ![]() ![]() Oxidation of the oxalate to carbon dioxide occurs by a series of steps that include the enzyme glyoxylate aminotransferase which requires thiamine pyrophosphate as a coenzyme. ![]() The high dose of vitamin C is also thought to increase the risk of kidney damage by leading to the formation of oxalate crystals. 7 It is understood to synergistically act with steroids to protect against and reverse vascular endothelial dysfunction caused by the endotoxin released during sepsis. Vitamin C is an essential water-soluble nutrient which plays a role in mediating inflammation through antioxidant activities and is also important in the synthesis of cortisol, catecholamines, and vasopressin, which are key mediators in the disease process. High cellular production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) contributes to oxidative stress, leading to consequent tissue and organ damage. 6 Widespread distribution of proinflammatory mediators plays an important role in the pathogenesis and high morbidity and mortality associated with sepsis. Sepsis is the result of a complex interaction between the host response and infecting organism resulting in severe organ dysfunction. 3, 4 Besides the short-term mortality, septic patients suffer from numerous short- and long-term complications, with a reduced quality of life and an increased risk of death following acute event. 1, 2 Given the high burden of sepsis worldwide, the search continues for effective targeted therapies in improving sepsis outcomes, especially in developing countries with a focus on inexpensive, safe, and accessible interventions. More than 5 million deaths globally could be attributed to sepsis. Sepsis remains as a life-threatening medical condition of dysregulated immune response with a mortality rate exceeding 50% in septic shock. ![]()
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